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Methods: Diagnostic groups included HC (n=26), anxiety disorder (AD) without MDD (n=40), and MDD (n=37). For the latter group, participants had a diagnosis of current MDD at the time of the scan and were presenting for inpatient admission for treatment.

Results: Significant positive correlations between childhood emotional abuse and lifetime MDD were observed without corrections for a potential inflated false positive rate (P=0.001, FDR).

Methods: All participants were scanned while performing a vigilance task, in which the left and right visual hemifield were presented. In each hemifield, distractors, TtNRTs (intercepts) and errors (slopes) were recorded. To exclude the possible influence of sleep-dependent performance changes, the participants with the night spent in the MRI scanner immediately before the day period of the scanning were excluded (n=33) from the correlation analysis and from the post-hoc two-sample t-test. The remaining participants (n=20) were divided into patients (n=13) and controls (n=7). Spearman correlation analyses were performed to examine the relationships between various background factors and intercept and slope of RTs in the TtNRT task and in a vigilance task. Multiple regression was used to examine which background factors were significantly correlated with intercept and slope of RTs. Regression analyses were performed for intercept and slope of RTs separately. The following factors were examined in the regression model: the current depression score (HDRS or MADRS), the number of previous depressive episodes, the annual number of MDD episodes, the medical treatment after LAC administration, and childhood emotional abuse (CECA).

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